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modafinil will decrease the extent or result of pacritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.No distinct dose adjustment suggested when tofacitinib coadministered with strong CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with both equally reasonable CYP3A4 and powerful CYP2C19 inhibitors .Mo